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英语翻译In vitro,NSCs grown in suspension form floating clusters

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英语翻译
In vitro,NSCs grown in suspension form floating clusters termed
neurospheres.Because neurospheres are clonally derived from
neural stem cells,they provide a good experimental system for
studying neural cell differentiation,not only to obtain phenotypes
of potential therapeutic interest but also to define the basic mechanisms
that regulate the acquisition of a specific cell fate in the
nervous system.Sowe examined the role of integrin \x024 on the generation
of neurons and gliacytes from NSCs by using neurospheres.
Increasing evidence indicates that integrin \x024 induces cell differentiation
(Stagge et al.,2001).Additionally,the cytoplasmic
domain of the \x024 subunit is directly involved in signaling events
that generate monocytic differentiation (Morena et al.,2002).
英语翻译In vitro,NSCs grown in suspension form floating clusters
在试管内,生长在悬浊液中的浮游团状物NSCs被称作神经球,因为神经球是由中枢神经干细胞克隆来的,它们为研究中枢神经细胞的分化提供了很好的实验系统,不仅仅为潜在治疗学方面获取表现型;也定义了一个基本机制,在神经系统里,规范了对特殊细胞命运的获取过程.一些人通过使用神经球,对在神经元子代和NSCs的胶质细胞上的integrin 4做了检测,确定了它的作用.越来越多的证据表明,integrin 4是细胞分化的诱导因素(Stagge et al.,2001).此外,integrin 4亚族的细胞质区域也涉及到信号传递事件,产生了单核细胞的分化.
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