搜搜做题作业网英语翻译Family-based designs for genome-wide association studies
来源：学生作业帮 编辑：搜搜做题作业网作业帮 分类：英语作业 时间：2024/07/13 06:50:03
英语翻译
Family-based designs for genome-wide association studies
Association mapping has successfully identified common SNPs associated with many diseases.However,the inability of this class of variation to account for most of the supposed heritability has led to a renewed interest in methods — primarily linkage analysis — to detect rare variants.Family designs allow for control of population stratification,investigations of questions such as parent-of-origin effects and other applications that are imperfectly or not readily addressed in case–control association studies.This article guides readers through the interface between linkage and association analysis,reviews the new methodologies and provides useful guidelines for applications.Just as effective SNP-genotyping tools helped to realize the potential of association studies,next-generation sequencing tools will benefit genetic studies by improving the power of family-based approaches.
Family-based designs for genome-wide association studies
Association mapping has successfully identified common SNPs associated with many diseases.However,the inability of this class of variation to account for most of the supposed heritability has led to a renewed interest in methods — primarily linkage analysis — to detect rare variants.Family designs allow for control of population stratification,investigations of questions such as parent-of-origin effects and other applications that are imperfectly or not readily addressed in case–control association studies.This article guides readers through the interface between linkage and association analysis,reviews the new methodologies and provides useful guidelines for applications.Just as effective SNP-genotyping tools helped to realize the potential of association studies,next-generation sequencing tools will benefit genetic studies by improving the power of family-based approaches.
家族式图案为基因组相关研究
协会已成功地确认了共同映射相关snp许多疾病.然而,这类变化不占大多数的应该导致遗传性有了新的兴趣连锁分析方法- - - - - - - - - - -主要是检测罕见的变体.家庭设计允许控制人群分层、调查的问题如parent-of-origin效果和其他应用程序的不完全或不容易解决的关联研究病例对照.本文通过引导读者之间的界面链和关联分析,回顾了新方法和应用提供有用的指导.正如SNP-genotyping工具帮助实现有效的潜在相关研究比较下一代定序工具将通过提高效益的遗传学研究的力量的方法.家族式
协会已成功地确认了共同映射相关snp许多疾病.然而,这类变化不占大多数的应该导致遗传性有了新的兴趣连锁分析方法- - - - - - - - - - -主要是检测罕见的变体.家庭设计允许控制人群分层、调查的问题如parent-of-origin效果和其他应用程序的不完全或不容易解决的关联研究病例对照.本文通过引导读者之间的界面链和关联分析,回顾了新方法和应用提供有用的指导.正如SNP-genotyping工具帮助实现有效的潜在相关研究比较下一代定序工具将通过提高效益的遗传学研究的力量的方法.家族式
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